MOTs-C peptide, also known as mitochondria-encoded senescence-associated secretory phenotype, is a small signaling peptide that plays a critical role in regulating cellular senescence and aging. This peptide is generated from the mitochondrial genome and acts as a key mediator of the senescence-associated secretory phenotype (SASP), which is characterized by the secretion of inflammatory cytokines and other bioactive molecules by senescent cells.

By targeting specific receptors on neighboring cells, MOTs-C peptide can modulate various cellular processes such as inflammation, cell proliferation, and tissue regeneration. Research has shown that manipulating MOTs-C levels can have significant effects on age-related diseases and longevity, making it a promising target for therapeutic interventions aimed at slowing down the aging process and improving overall healthspan.